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Request for Proposal: 28-day GLP repeat-dose toxicology (2 species)
| Issued by | [Company name] |
| Contact | [Contact name and email] |
| Date issued | 31 August 2026 |
| Response deadline | [Deadline] |
| Molecule / program | [Brief molecule description: class, modality, stage] |
| Indication | [Indication] |
| Target timeline | [When the work should start / complete] |
| Budget guidance | Not disclosed; please quote your standard pricing |
1. Scope of work
We are requesting proposals for a 28-day GLP repeat-dose toxicology program in rodent and non-rodent species to support a first-in-human IND filing. The program should follow ICH M3(R2) expectations and 21 CFR Part 58 GLP.
2. Study design and technical requirements
Anticipated design: 4 groups (vehicle plus 3 dose levels) with standard group sizes for each species, toxicokinetic satellite animals in the rodent arm, recovery cohorts on control and high dose, standard clinical pathology, full ophthalmology, and complete histopathology on the standard tissue list. Dose levels will be finalized from our dose-range-finding data, which we will share under CDA.
3. Deliverables
Draft protocol for sponsor approval before start, in-life updates at an agreed cadence, audited draft report within an agreed window after necropsy, and a final GLP report suitable for IND submission. Please state your standard draft-report timeline from last necropsy.
4. Quote structure requested
Please quote each species as a separate line item, state what is included (in-life, clinical pathology, histopathology, TK analysis, QA) and what is a pass-through (animal acquisition, formulation analysis, shipping, archiving), give your change-order rate basis, and state the earliest available study start slot. If bioanalytical support is quoted separately, say so explicitly.
5. Vendor questions (please answer in your response)
Confirm GLP compliance status and most recent regulatory inspection outcome. Confirm species availability and current lead time. Describe your experience with this modality. State report QC turnaround and raw data ownership terms.
6. General requirements
Please disclose all pass-through costs and their estimation basis in your quote.
State your change-order process and rates before study start.
Confirm data ownership: the sponsor owns all raw data, reports, and (where applicable) cell lines or methods generated under this work.
Confirm your quality system status (GLP/GMP as applicable) and most recent inspection outcome.
Quotes should remain valid for at least 60 days.
Please respond by the deadline below; questions before then are welcome.
The document above is yours to use anywhere: send it to CROs directly, or post the same content once on BioBridgeX and receive comparable quotes from vetted suppliers in the 28-day glp repeat-dose toxicology (2 species) category. Free for buyers, no email gate on this tool.
Common questions
What should a CRO RFP include?
Six things: a clear scope of work, the study design and technical requirements, the deliverables you expect, the quote structure you want bids in (so they come back comparable), the vendor questions they must answer, and your general terms on pass-throughs, change orders, and data ownership. The generator pre-fills all six for your study type.
How many CROs should I send an RFP to?
Three to five is the practical range. Fewer than three and you have no price discovery; more than five and the evaluation work outweighs the benefit. Quotes for the same study routinely differ 2 to 3x, so the comparison itself is worth real money.
Is this really free, and do you keep my information?
Free, no signup, and the document is built entirely in your browser: nothing you type here is uploaded anywhere. Download it as Word or PDF and use it however you like.
What is the difference between an RFP and an RFQ?
An RFP asks suppliers to propose an approach and a price; an RFQ asks for a price against a defined scope. For well-defined studies (a 28-day GLP tox study, an Ames battery) the documents converge, which is why this generator produces something you can use as either.
Can I post this directly to BioBridgeX instead of emailing CROs?
Yes. The sections here map onto the BioBridgeX project form. Post the same content once, and vetted suppliers in the right category respond with structured quotes you can compare side by side. Free for buyers; suppliers pay a 2 percent success fee only when awarded and paid.
Before you send it
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